Yes of course - possible workflow would be:
Create a plugin to modify your model - see this code sample here
Bundle your plugin to upload to Forge and define an activity for execution - see tutorial here
Load the model into Viewer after translating it with Model Derivative
Collect the data/parameter from user input and/or model properties/metadata
Call a workitem with the parameters and execute the plugin, can upload the modified output as versioned items to track changes
Use webhooks to get notified of new version being added and trigger a translation of it, or you can upload the output to your own app and trigger upload and translation with your own workflow
Load the modified model back into Viewer
See here for our official tutorial on Design Automation.