Multiply list of lists with elements of multiplier list Python

If you'll convert your code from list comprehension into simple loop, you will see where problem is:

result = []
for a, b in zip(multiplier, list_of_lists):
    result.append(a * b)  # appends a copies of list b

It's definitely not what you're trying to do. You need nested loop to iterate over items of inner lists:

result = []
for multiplier, sub_list in zip(multipliers, list_of_lists):
    new_list = []
    for item in sub_list:
        new_list.append(multiplier * item)
    result.append(new_list)

Or you can write it shorter using nested list comprehension (you can give variables shorter names to look more "compact"):

result = [[multiplier * item for item in sub_list] for multiplier, sub_list in zip(multipliers, list_of_lists)]